학술논문

Frequency of an X-Linked Maternal Variant of the Bovine FOXP3 Gene Associated with Infertility in Different Cattle Breeds: A Pilot Study.
Document Type
Article
Source
Animals (2076-2615). Apr2022, Vol. 12 Issue 8, pN.PAG-N.PAG. 7p.
Subject
*CATTLE crossbreeding
*CATTLE breeding
*INFERTILITY
*CATTLE breeds
*BOS
*VETERINARY medicine
*GENES
Language
ISSN
2076-2615
Abstract
Reporter assays indicated that this SNP G allele was associated with reduced levels of I FOXP3 i transcription, which may be a maternal immunogenic factor underlying the identified association between recurrent infertility in repeat breeding cows and higher frequencies of the G allele [[9]]. In the present study, we established that compared with cows of the other three breeds, these cattle have a notably high likelihood of carrying the G allele (0.700), and we speculate that this high G allele frequency could be attributable to the genetic contribution of banteng cattle. Given that the moderate to high G allele frequencies in IM and HF cows are plausibly associated with the infertility of these breeds, it would be interesting to evaluate the relationship between the high frequency of the risk-type G allele and infertility. HF, JB, and KH cows were characterized by a predominant A allele at this locus, whereas in IM cows, the G allele was detected more frequently than the A allele. [Extracted from the article]