부산대학교 도서관

The drivers behind regional differences of SARS-CoV-2 spread on finer spatio-temporal scales are yet to be fully understood. Here we develop a data-driven modelling approach based on an age-structured compartmental model that compares 116 Austrian regions to a suitably chosen control set of regions to explain variations in local transmission rates through a combination of meteorological factors, non-pharmaceutical interventions and mobility. We find that more than 60% of the observed regional variations can be explained by these factors. Decreasing temperature and humidity, increasing cloudiness, precipitation and the absence of mitigation measures for public events are the strongest drivers for increased virus transmission, leading in combination to a doubling of the transmission rates compared to regions with more favourable weather. We conjecture that regions with little mitigation measures for large events that experience shifts toward unfavourable weather conditions are particularly predisposed as nucleation points for the next seasonal SARS-CoV-2 waves. Author summary: How weather modulates the spread of SARS-CoV-2 on fine spatio-temporal scales is still not fully understood. Here we use a controlled regional comparison to isolate the impact of five different meteorological factors, four types of non-pharmaceutical interventions as well as individual-level mobility on transmission rates in Austria. We find that more than 60% of regional variations can be explained by these factors. Temperature and humidity relate inversely with transmission rates whereas cloudiness and precipitation correlate with increasing transmission. We also observe a particularly strong impact of restrictions targeting large events. Our results suggest that a combination of weather shifts towards winter conditions combined with little mitigation measures for large gatherings drive the early growth of seasonal SARS-CoV-2 waves. [ABSTRACT FROM AUTHOR]