학술논문
Chemical constituents and antibacterial activity from the stems and leaves of Piper wallichii.
Document Type
Article
Author
Source
Subject
*NUCLEAR magnetic resonance spectroscopy
*BACILLUS (Bacteria)
*PHYTOCHEMICALS
*PLANT stems
*LEAVES
*STAPHYLOCOCCUS aureus
*MASS spectrometry
*RESEARCH funding
*PLANT extracts
*MOLECULAR structure
*CHROMATOGRAPHIC analysis
*ANTIBIOTICS
*PHARMACODYNAMICS
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Language
ISSN
1028-6020
Abstract
A phytochemical investigation of the stems and leaves of Piper wallichii led to the isolation of two new compounds, an aryl alkanone, piwalkanone (1) and a dioxoaporphine alkaloid, piwallidione (2), together with nine known compounds, a dioxoaporphine alkaloid, cepharadione A (3); two aristolactams, piperolactam A (4) and stigmalactam (5); a piperidine, piperine (6); four isobutylamides, piperlonguminine (7), pellitorine (8), N‐isobutyl‐2E,4E‐octadecadienamide (9), and guineensine (10); and a tyramine, N-trans-feruloyltyramine (11). Their structures were elucidated on the basis of spectroscopic evidence (IR, 1H NMR, 13C NMR and 2 D NMR) and MS. Compounds 2 and 3 showed inhibitory activities against pathogenic bacteria, Bacillus cereus, Bacillus subtilis and Staphylococcus aureus. [ABSTRACT FROM AUTHOR]