부산대학교 도서관

Across the Pacific, and including in the Solomon Islands, outbreaks of arboviruses such as dengue, chikungunya, and Zika are increasing in frequency, scale and impact. Outbreaks of mosquito-borne disease have the potential to overwhelm the health systems of small island nations. This study mapped the seroprevalence of dengue, Zika, chikungunya and Ross River viruses in 5 study sites in the Solomon Islands. Serum samples from 1,021 participants were analysed by ELISA. Overall, 56% of participants were flavivirus-seropositive for dengue (28%), Zika (1%) or both flaviviruses (27%); and 53% of participants were alphavirus-seropositive for chikungunya (3%), Ross River virus (31%) or both alphaviruses (18%). Seroprevalence for both flaviviruses and alphaviruses varied by village and age of the participant. The most prevalent arboviruses in the Solomon Islands were dengue and Ross River virus. The high seroprevalence of dengue suggests that herd immunity may be a driver of dengue outbreak dynamics in the Solomon Islands. Despite being undetected prior to this survey, serology results suggest that Ross River virus transmission is endemic. There is a real need to increase the diagnostic capacities for each of the arboviruses to support effective case management and to provide timely information to inform vector control efforts and other outbreak mitigation interventions. Author summary: The occurrence of arboviruses is increasing and causing significant impacts on human health. This is of high concern in small Pacific island nations where fragile health systems are regularly overwhelmed by disease outbreaks. To effectively prevent and control disease transmission there is a need to understand which viruses have been in circulation. Therefore, we conducted a cross-sectional survey of residents from 5 study sites distributed across the Solomon Islands. The serum samples were tested for antibodies that indicate prior infection for four arboviruses. We found evidence that the residents of the Solomon Islands have been exposed to substantial transmission of dengue and Ross River viruses, with lower levels of Zika and chikungunya transmission. Two large dengue outbreaks have been recently experienced and the outbreak pattern suggests that natural herd immunity may still be a driver of dengue outbreak dynamics in the Solomon Islands. Regarding Ross River virus, transmission is endemic despite being undetected prior to this survey. There is a real need to increase the capacity to accurately diagnose each of these arboviruses to support effective case management and to provide timely information to inform vector control efforts. [ABSTRACT FROM AUTHOR]