학술논문
Association Between Soluble Notch Ligand Delta-like Ligand 1 and Bleeding Complications in Patients With Dengue Fever Infection.
Document Type
Journal Article
Author
Source
Subject
*DENGUE hemorrhagic fever
*DENGUE
*ENZYME-linked immunosorbent assay
*RECEIVER operating characteristic curves
*HEMORRHAGE
*ASPARTATE aminotransferase
*RESEARCH
*RESEARCH methodology
*EVALUATION research
*COMPARATIVE studies
*RESEARCH funding
*ALANINE aminotransferase
*LIGANDS (Biochemistry)
*DISEASE complications
*
*
*
*
*
*
*
*
*
*
*
*
*
Language
ISSN
0022-1899
Abstract
Bleeding associated with endothelial damage is a key feature of severe dengue fever. In the current study, we investigated whether Notch ligands were associated with bleeding in 115 patients with confirmed dengue infection in Vietnam. Soluble Notch ligands were determined by means of enzyme-linked immunosorbent assay. Seventeen of 115 patients (14.8%) experienced bleeding manifestations. High soluble delta-like ligand 1 (sDLL1) plasma levels was associated with bleeding (median, 15 674 vs 7117 pg/mL; P < .001). Receiver operating characteristic (ROC) curve analysis demonstrated that sDLL1 had the best test performance (area under the ROC curve, 0.852), with 88% sensitivity and 84% specificity. The combination with alanine aminotransferase and aspartate aminotransferase slightly increased sDLL1 performance. sDLL1 may be useful to guide clinical management of patients with patients in endemic settings. [ABSTRACT FROM AUTHOR]