학술논문
Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia.
Document Type
Case Study
Author
Source
Subject
*MYELOID sarcoma
*ACUTE leukemia
*RUXOLITINIB
*MYELOPROLIFERATIVE neoplasms
*CHIMERIC proteins
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Language
ISSN
2050-0904
Abstract
The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1‐JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1‐JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL. [ABSTRACT FROM AUTHOR]