학술논문
HLA alleles associated with asparaginase hypersensitivity in Chinese children.
Document Type
Article
Author
Chua, Gilbert T.; Rosa Duque, Jaime S.; Cheuk, Daniel Ka Leung; Leung, Alex Wing Kwan; Wong, Wilfred Hing Sang; Liu, Anthony Pak Yin; Lee, Pamela P. W.; Ha, Shau Yin; Chiang, Alan Kwok Shing; Ho, Marco Hok Kung; Chu, Wai Keung; Chan, Yuk Sing; Luk, Chun Wing; Ling, Alvin Siu Cheung; Kwan, Mike Yat Wah; Yiu, Oscar Kuen Fong; Wong, Ian Chi Kei; Lau, Yu Lung; Li, Chi Kong; Leung, Wing Hang
Source
Subject
*CHINESE people
*ASPARAGINASE
*HLA histocompatibility antigens
*ALLERGIES
*NON-Hodgkin's lymphoma
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Language
ISSN
1756-8722
Abstract
Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6–11.4, p < 0.01) were significantly associated with l-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p < 0.01)]. [ABSTRACT FROM AUTHOR]