학술논문
Natural moisturizing factor as a biomarker for filaggrin mutation status in a multi‐ethnic paediatric atopic dermatitis cohort.
Document Type
Article
Author
Source
Subject
*ATOPIC dermatitis
*FILAGGRIN
*BIOMARKERS
*PEDIATRICS
*CHILD patients
*PEDIATRIC dermatology
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Language
ISSN
0954-7894
Abstract
Furthermore, the NMF content in patients with a single mutation in I FLG i was significantly different compared to both wild-type patients and patients with 2 mutations in I FLG i ( I p i < .01, Figure S2). The aim of our study was to screen the entire encoding region of I FLG i for potential mutations and to validate whether NMF could be used as a biomarker for I FLG i genotype in an unselected multi-ethnic clinical cohort of children with mild-to-severe disease. Raman spectroscopy is a rapid and non-invasive technique to measure natural moisturizing factor content in AD Natural moisturizing factor can predict I FLG i genotype with a sensitivity of 97% and specificity of 87% The thenar eminence's nonlesional skin is a suitable location to predict I FLG i genotype To the Editor, Atopic dermatitis (AD) is a common inflammatory skin disease among children with increasing prevalence in the past decades. [Extracted from the article]