학술논문
Variant rs6596140 of Follistatin-like 4 Gene (FSTL4) May Be Associated with Poor Response to Angiotensin Receptor Blockers (ARBs) among Filipinos.
Document Type
Article
Author
Ona, Deborah Ignacia D.; Nevado, Jose B.; Ramos, John Daniel A.; Llanes, Elmer Jasper B.; Magno, Jose Donato A.; Punzalan, Felix Eduardo R.; Reganit, Paul Ferdinand M.; Santos, Lourdes Ella G.; Tiongco II, Richard Henry P.; Aherrera, Jaime Alfonso M.; Abrahan IV, Lauro L.; Agustin, Charlene F.; Aman, Aimee Yvonne Criselle L.; Bejarin, Adrian John P.; Cutiongco–de la Paz, Eva Maria C.; Sy, Rody G.
Source
Subject
*ANGIOTENSIN receptors
*GENETIC variation
*FILIPINOS
*ANTIHYPERTENSIVE agents
*SINGLE nucleotide polymorphisms
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Language
ISSN
0031-7683
Abstract
Constituting one of the most commonly used antihypertensive drug families are the angiotensin receptor blockers (ARBs). The aim of this study was to identify the variants associated with response to ARBs that may potentially be used as markers for designing a tailor-fit treatment strategy for hypertension. An unmatched case-control study was done among adult hypertensive Filipino patients maintained on ARBs. Genotypic analysis of blood DNA was conducted. Logistic regression analyses were performed to determine association of clinical and genetic variables with ARB response. A total of 69 poor responders and 126 normal responders were included in the study. After performing univariate logistic regression, five single nucleotide polymorphisms showed association with poor response to ARBs. The genetic variant rs6596140 remained significant (dominant model; OR 2.36, p = 0.009) after adjusting for female sex and age. Variant rs6596140 was found to be associated with poor response to ARBs among Filipinos. Prior to clinical application, verification is recommended prior to clinical application. As the function of this variant is presently unknown, an investigation to elucidate its role in ARB response in hypertension is also recommended. [ABSTRACT FROM AUTHOR]