부산대학교 도서관

Intervertebral disc disease (IVDD) refers to degenerative processes of the spine resulting in reduced shock-absorbing ability, which may ultimately lead to disc herniation and spinal cord compression. Since PI3K/Akt pathway might be inhibited by cytokine-induced inflammation and, in the same way, activated by resveratrol, this latter could be imagined as apoptotic suppressant (and maybe autophagic activator) in the context of disc degeneration. Molecular analysis found out that cells treatment, in presence of RSV and ES, improved cell viability, suppressed by the presence of IL-1 , whereas diminished cells apoptosis, induced by the same cytokine. [Extracted from the article]