학술논문
Sex Cord Tumor With Annular Tubules–Like Histologic Pattern in Adult Granulosa Cell Tumor: Case Report of a Hitherto Unreported Morphologic Variant.
Document Type
Article
Author
Source
Subject
*GRANULOSA cell tumors
*OVARIAN tumors
*UMBILICAL cord clamping
*TUMORS
*ADULTS
*INCIDENTAL learning
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Language
ISSN
1066-8969
Abstract
Adult granulosa cell tumor (AGCT) and sex cord tumor with annular tubules (SCTAT) are distinct sex cord stromal tumors with different molecular signatures. We present a unique case of an incidental ovarian tumor with mixed AGCT and SCTAT morphologic patterns. Due to the unusual co-occurrence, molecular testing was separately performed on both components. Despite minimal overlap in morphology, both the SCTAT and AGCT components were found to have an identical mutation profile, including the prototypical FOXL2 p.C134W mutation characteristic of AGCT. We thus present the first report of AGCT with SCTAT-like pattern. [ABSTRACT FROM AUTHOR]