학술논문
Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers.
Document Type
Article
Author
Ho, Peh Joo; Yeoh, Yen Shing; Miao, Hui; Lim, Swee Ho; Tan, Ern Yu; Tan, Benita Kiat Tee; Tan, Veronique Kiak Mien; Tan, Su Ming; Yong, Wei Sean; Wong, Fuh Yong; Madhukumar, Preetha; Chan, Ching Wan; Iau, Philip Tsau Choong; Lee, Soo Chin; Putti, Thomas; Buhari, Shaik Ahmad; Lee, Jin Yee; Lim, Geok Hoon; Woo, Evan; Yan, Zhiyan
Source
Subject
*GENETIC markers
*BREAST cancer
*OVARIAN cancer
*RISK assessment
*BREAST cancer research
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Language
ISSN
1932-6203
Abstract
This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers. [ABSTRACT FROM AUTHOR]