학술논문
Presence of Ebola virus in breast milk and risk of mother-to-child transmission: synthesis of evidence.
Document Type
Article
Author
Medina-Rivera, Melisa; Centeno-Tablante, Elizabeth; Finkelstein, Julia L.; Rayco-Solon, Pura; Peña-Rosas, Juan Pablo; Garcia-Casal, Maria N.; Rogers, Lisa; Ridwan, Pratiwi; Martinez, Sabrina Sales; Andrade, Joyce; Layden, Alexander J.; Juan Chang; Zambrano, Mildred P.; Ghezzi-Kopel, Kate; Mehta, Saurabh
Source
Subject
*BREAST milk
*EBOLA virus
*BREASTFEEDING
*PERSPIRATION
*VIRAL transmission
*EVIDENCE
*TEXT files
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Language
ISSN
0077-8923
Abstract
To help inform global guidelines on infant feeding, this systematic review synthesizes evidence related to the presence of the Ebola virus (EBOV) in breastmilk and its potential risk of viral transmission to the infant when breastfeeding. We relied on a comprehensive search strategy to identify studies including women with suspected, probable, or confirmed EBOV infection, intending to breastfeed or give breast milk to an infant. Our search identified 10,454 records, and after deduplication and screening, we assessed 148 full texts. We included eight studies reporting on 10 breastfeedingmothers and their children (one mother with twins), who provided breast milk samples for assessment. EBOV was detected via RT-PCR or viral culture in seven out of ten breast milk samples. Four out of the five-breastfed infants with EBOV-positive breast milk were found positive for EBOV infection, and all of these EBOV-positive infants died. Since previous reports have detected EBOV in tears, saliva, sweat, and contaminated surfaces, with the current evidence, it is not possible to concludewith certainty that breast milk was themain route of EBOV transmission. [ABSTRACT FROM AUTHOR]