학술논문
The clinical spectrum of COVID-19-associated cutaneous manifestations: An Italian multicenter study of 200 adult patients.
Document Type
Academic Journal
Author
Marzano, Angelo Valerio; Genovese, Giovanni; Moltrasio, Chiara; Gaspari, Valeria; Vezzoli, Pamela; Maione, Vincenzo; Misciali, Cosimo; Sena, Paolo; Patrizi, Annalisa; Offidani, Annamaria; Quaglino, Pietro; Arco, Renato; Caproni, Marzia; Rovesti, Miriam; Bordin, Giorgio; Recalcati, Sebastiano; Potenza, Concetta; Guarneri, Claudio; Fabbrocini, Gabriella; Tomasini, Carlo; et al
Source
Subject
Language
English
ISSN
0190-9622
Abstract
Background: COVID-19 is associated with a wide range of skin manifestations.Objective: To describe the clinical characteristics of COVID-19-associated skin manifestations and explore the relationships among the 6 main cutaneous phenotypes and systemic findings.Methods: Twenty-one Italian Dermatology Units were asked to collect the demographic, clinical, and histopathologic data of 200 patients with COVID-19-associated skin manifestations. The severity of COVID-19 was classified as asymptomatic, mild, moderate, or severe.Results: A chilblain-like acral pattern was significantly associated with a younger age (P < .0001) and, after adjusting for age, significantly associated with less severe COVID-19 (P = .0009). However, the median duration of chilblain-like lesions was significantly longer than that of the other cutaneous manifestations taken together (P < .0001). Patients with moderate/severe COVID-19 were more represented than those with asymptomatic/mild COVID-19 among the patients with cutaneous manifestations other than chilblain-like lesions, but only the confluent erythematous/maculo-papular/morbilliform phenotype was significantly associated with more severe COVID-19 (P = .015), and this significance disappeared after adjustment for age.Limitations: Laboratory confirmation of COVID-19 was not possible in all cases.Conclusions: After adjustment for age, there was no clear-cut spectrum of COVID-19 severity in patients with COVID-19-related skin manifestations, although chilblain-like acral lesions were more frequent in younger patients with asymptomatic/pauci-symptomatic COVID-19.