부산대학교 도서관

A survey of the literature indicates that the developmental disruptions in serotonin (5‐HT) levels can influence the brain development and the function. To the best of our knowledge, so far, there are a few studies about the effects of developmental period 5‐HT depletion on cognition and behavior of adult male and female rats. Therefore, in the present study, we examined the effects of postnatal days (PND 10–20) administration of para‐chlorophenylalanine (PCPA, 100 mg/kg, s.c) a 5‐HT synthesis inhibitor, on anxiety‐related behaviors, pain sensitivity, short‐term recognition memory, and hippocampal and prefrontal cortex (PFC) brain‐derived neurotrophic factor (BDNF) mRNA expression in adult male and female rats. Novel object recognition memory (NORM) and behavioral parameters (anxiety‐like behaviors and pain sensitivity) were evaluated in early adulthood and after that, the hippocampi and PFC of the rat's brain were removed for the determination of BDNF mRNA expression. Our results indicated that the postnatal period administration of PCPA impaired short‐term NORM. The postnatal developmental period treatment with PCPA also increased anxiety‐like behaviors in the open field and elevated plus maze (EPM) tests. Postnatal PCPA treatment increased pain sensitivity in the hot plate test in both male and female rats, especially in female animals. In addition, postnatal days serotonin depletion decreased BDNF level in the hippocampus and PFC of both male and female rats. These findings demonstrate that serotonin plays the main role in neurodevelopment, cognitive functions, and behavior. Therefore, serotonergic system dysregulation during the developmental periods may have more adverse influences on the brain development of rats. [ABSTRACT FROM AUTHOR]