학술논문
Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci.
Document Type
Journal Article
Author
Source
Subject
*PENICILLIN-binding proteins
*MENINGOCOCCAL infections
*NEISSERIA
*NEISSERIA meningitidis
*PANDEMICS
*RESEARCH
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*MENINGOCOCCAL vaccines
*SEROTYPES
*COMPARATIVE studies
*GRAM-negative aerobic bacteria
*QUINOLONE antibacterial agents
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Language
ISSN
1080-6040
Abstract
Expansion of quinolone-resistant Neisseria meningitidis clone ChinaCC4821-R1-C/B from sequence type (ST) 4821 clonal complex (CC4821) caused a serogroup shift from serogroup A to serogroup C invasive meningococcal disease (IMD) in China. To determine the relationship among globally distributed CC4821 meningococci, we analyzed whole-genome sequence data from 173 CC4821 meningococci isolated from 4 continents during 1972-2019. These meningococci clustered into 4 sublineages (1-4); sublineage 1 primarily comprised of IMD isolates (41/50, 82%). Most isolates from outside China (40/49, 81.6%) formed a distinct sublineage, the Europe-USA cluster, with the typical strain designation B:P1.17-6,23:F3-36:ST-3200(CC4821), harboring mutations in penicillin-binding protein 2. These data show that the quinolone-resistant clone ChinaCC4821-R1-C/B has expanded to other countries. The increasing distribution worldwide of serogroup B CC4821 raises the concern that CC4821 has the potential to cause a pandemic that would be challenging to control, despite indirect evidence that the Trumenba vaccine might afford some protection. [ABSTRACT FROM AUTHOR]