학술논문

Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype.
Document Type
Journal Article
Source
CHEST. Mar2021, Vol. 159 Issue 3, p963-966. 4p.
Subject
*SARS-CoV-2
*PHENOTYPES
*REVERSE transcriptase polymerase chain reaction
*RESEARCH funding
Language
ISSN
0012-3692
Abstract
To the Editor: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) pneumonia may induce an aberrant immune response with brisk recruitment of myeloid cells into the airspaces.[1] Although the clinical implications are unclear, others have suggested that infiltrating myeloid cells may contribute to morbidity and mortality rates during SARS-CoV-2 infection.[[1]] However, few reports have characterized myeloid cells from the lower respiratory tract, which appears to be the primary site of viral-induced disease, during severe SARS-CoV-2 pneumonia. C, Comparison of endotracheal aspirate cells that co-expressed CD14 (14) or CD16 (16) with (N+) or without (N-) SARS-CoV-2 nucleocapsid protein in each sample (n=5 patients; patient 2 was removed due to low number of cells with nucleocapsid protein). [Extracted from the article]