부산대학교 도서관

Global urbanization is leading to an inexorable spread of several major diseases that need to be stemmed. Dengue is one of these major diseases spreading in cities today, with its principal mosquito vector superbly adapted to the urban environment. Current mosquito control strategies are proving inadequate, especially in the face of such urbanisation and novel, evidence-based targeted approaches are needed. Through combined epidemiological and entomological approaches, we aimed to identify a novel sanitation strategy to alleviate the burden of dengue through how the dengue virus spreads through the community. We combined surveillance case mapping, prospective serological studies, year-round mosquito surveys, socio-economic and Knowledge Attitudes and Practices surveys across Delhi. We identified lack of access to tap water (≤98%) as an important risk factor for dengue virus IgG sero-positivity (adjusted Odds Ratio 4.69, 95% C.I. 2.06–10.67) and not poverty per se. Wealthier districts had a higher dengue burden despite lower mosquito densities than the Intermediary income communities (adjusted Odds Ratio 2.92, 95% C.I. 1.26–6.72). This probably reflects dengue being introduced by people travelling from poorer areas to work in wealthier houses. These poorer, high density areas, where temperatures are also warmer, also had dengue cases during the winter. Control strategies based on improved access to a reliable supply of tap water plus focal intervention in intra-urban heat islands prior to the dengue season could not only lead to a reduction in mosquito abundance but also eliminate the reservoir of dengue virus clearly circulating at low levels in winter in socio-economically disadvantaged areas. Author summary: Identifying disease hotspots and individual risk factors for dengue can enable targeted intervention strategies. We conducted combined serological, entomological and socio-economic surveys across 18 areas within Delhi, taken from the total 1280 colonies (i.e. the administrative units of reference in Delhi) for which we classified their socio-economic typology. We additionally performed a Knowledge, Attitudes, Practices survey at a household level within the most socially disadvantaged sub-districts. Finally, we mapped all the winter dengue cases to 250 m x 250 m units along with their winter mean temperatures. We found that access to tap water was an important risk factor for exposure to dengue virus (DENV) and this was confirmed even within the socially disadvantaged sub-districts. The Wealthy colonies had a high burden of DENV infection despite low mosquito densities, likely linked to their connectedness through daily human mobility. The winter burden of dengue occurred majoritarily in the socio-economically disadvantaged colonies, which also have higher mean temperatures and urban heat islands. Improved access to tap water could lead to a reduction in dengue, not only for those directly affected but for the general population. Targeted intervention through mosquito control in winter in the socially disadvantaged areas could offer a rational strategy for optimising control efforts. [ABSTRACT FROM AUTHOR]