학술논문
Efficient Access to Isoquinolines via Rhodium-Catalyzed Oxidative Annulation of Pyridyl C–H Bonds Directed by Carbonyl with Internal Alkynes.
Document Type
Article
Author
Source
Subject
*RHODIUM catalysts
*ANNULATION
*STERIC hindrance
*ALKYNES
*AMINO group
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Language
ISSN
0039-7881
Abstract
An efficient synthesis of amino-substituted isoquinolines via Rh(III)-catalyzed oxidative [2+2+2] annulation of pyridines with alkynes has been developed, which is cooperatively enabled by a directing carbonyl and steric hindrance adjacent to the amino group of the pyridine, via a six-membered rhodacyclic intermediate without coordination with the pyridinic nitrogen. The establishment of this C–H activation strategy also paves the way for other oxidative transformations of heterocyclic C–H bonds. [ABSTRACT FROM AUTHOR]