학술논문
Differences in Sociodemographic and Alcohol‐Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder.
Document Type
Article
Author
Source
Subject
*AGE factors in disease
*ALCOHOLISM
*COMPARATIVE studies
*ALCOHOL drinking
*FORECASTING
*HELP-seeking behavior
*MATHEMATICAL statistics
*DISEASE relapse
*PARAMETERS (Statistics)
*SOCIOECONOMIC factors
*TREATMENT effectiveness
*ALCOHOL-induced disorders
*DESCRIPTIVE statistics
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Language
Abstract
Background: One of the challenges in early‐stage clinical research aimed at developing novel treatments for alcohol use disorder (AUD) is that the enrolled participants are heavy drinkers, but do not seek treatment for AUD. Aims: To compare nontreatment seekers with alcohol dependence (AD) from 4 human laboratory studies conducted at Brown University (N = 240; 65.4% male) to treatment seekers with AD from the multisite COMBINE study (N = 1,383; 69.1% male) across sociodemographic and alcohol‐related clinical variables and to evaluate whether the variables that significantly differentiate the 2 samples predict the 3 main COMBINE clinical outcomes: time to relapse, percent days abstinent (PDA), and good clinical outcome. Methods: Sample characteristics were assessed by parametric and nonparametric testing. Three regression models measured the association between the differing variables and the 3 main COMBINE clinical outcomes. Results: The nontreatment seekers, compared to the treatment seekers, were more ethnically diverse, less educated, single, and working part‐time or unemployed (p's < 0.05); they met fewer DSM‐IV AD criteria and had significantly lower scores on alcohol‐related scales (p's < 0.05); they were less likely to have a father with alcohol problems (p < 0.0001) and had a significantly earlier age of onset and longer duration of AD (p's < 0.05); they also had significantly more total drinks, drinks per drinking day, heavy drinking days (HDD), and lower PDA in the 30 days prior to baseline (p's < 0.0001 to <0.05). Having more HDD in the 30 days prior to baseline predicted all of the 3 COMBINE clinical outcomes. All the other characteristics mentioned above that differed significantly between the 2 groups predicted at least 1 of the 3 COMBINE clinical outcomes, except for level of education, age of onset, and duration of AD. Conclusions: The observed differences between groups should be considered in efforts across participant recruitment at different stages of the development of new treatments for AUD. [ABSTRACT FROM AUTHOR]