부산대학교 도서관

Importance Understanding visual impairment (VI) under different definitions and potential risk factors in high myopic is important for future myopia control. Background: Limited studies exists investigating the VI among high myopic and with varying VI definitions. Design Registry cohort study. Participants: Eight hundred and eighty‐four participants were from ZOC‐BHVI study. Methods: Subjects aged 7 to 70 years with high myopia were enrolled. Uncorrected visual acuity and best‐corrected visual acuity (UCVA and BCVA), cycloplegic refraction, axial length (AL), corneal curvatures, anterior chamber depth and lens thickness were measured. Axial length/corneal radius of curvature ratio (AL/CR ratio) was calculated. Fundus lesions were graded into five categories. VI and blindness were defined based on the better‐seeing eye according to the World Health Organization (WHO) criteria and US criteria. Multiple logistic regression analysis was used to assess risk factors for VI. Main Outcome Measures: Rates of VI and blindness. Results: A total of 884 participants were included, with mean (SD) age 18.5 (12.4) years and 46.4% male. Rate of UCVI/blindness were 72.6%/27.3% and 17.9%/82.1% based on WHO and US criteria. With respect to BCVA, 4.1%/5.9% of participants had BCVI using two definitions, whereas the rate for blindness was 0.2% and 0.6%. After adjusting confounders, multiple logistic regression showed that more severe fundus lesions, greater AL/CR ratio were at a higher risk of being VI, both in two definitions (P <.005). Conclusions and Relevance: The rate of VI and blindness in highly myopic patients varies significantly using different definition. Severe fundus lesions and greater AL/CR ratios were associated with a higher risk of VI. [ABSTRACT FROM AUTHOR]