부산대학교 도서관

Objectives: To estimate the prevalence of personality disorders in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and compare it with general population and analyze their implications on treatment outcome. Materials and Methods: TLE was diagnosed based on clinical history, MRI, and Video EEG data. IPDE‐ICD10 screening questionnaire was applied to investigate personality disorder in 120 subjects, 60 cases, and 60 normal controls. Bear‐Fedio inventory (BFI) was used to study different behavior traits in patients with TLE and controls. Results: Prevalence of personality disorders was higher (71.7% in cases versus 38.3% in controls) in patients with TLE compared to controls (P <.001). Some personality traits like schizoid (P =.002), dissocial (P =.001), impulsive (P =.003), anankastic (P <.001), anxious (P <.001), and dependent (P <.001) personalities were found to have high prevalence in TLE. Personality disorder was higher among those cases who had been tried on more than two antiepileptic drugs (AEDs) (P =.033) and in those with duration of illness more than 10 years (P =.026). Cases also showed significantly higher score in BFI for all behavioral traits except for aggression. No significant difference of BFI score was seen based on laterality of epileptic focus, gender, duration of illness, or number of AEDs tried. Conclusion: There is a significantly higher prevalence of personality disorders in patients with TLE. Specific interventions for these disorders should be considered at the earliest pari passu with AEDs and surgery. [ABSTRACT FROM AUTHOR]