학술논문
New insights into the pathogenesis of Streptococcus pneumoniae–associated hemolytic uremic syndrome.
Document Type
Article
Source
Subject
*HEMOLYTIC-uremic syndrome treatment
*THERAPEUTIC use of monoclonal antibodies
*GLYCOSIDASES
*HEMOLYTIC-uremic syndrome
*IMMUNITY
*PLASMAPHERESIS
*STREPTOCOCCAL diseases
*TUMOR antigens
*VIRAL antigens
*DISEASE complications
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Language
ISSN
0931-041X
Abstract
The purpose of this review is to describe Streptococcus pneumoniae–associated hemolytic uremic syndrome (P-HUS) with emphasis on new insights into the pathophysiology and management over the past 10 years. Even though awareness of this clinico-pathological entity has increased, it likely remains under-recognized. Recent observations indicate that although neuraminidase activity and exposure of the T-antigen are necessary for development of P-HUS, they are not sufficient; activation of the alternate pathway of complement may also contribute. It is unclear, however, whether or not eculizumab and/or plasmapheresis are of value. [ABSTRACT FROM AUTHOR]