부산대학교 도서관

Background: There is still a lack of a clinical test to reliably identify patients with Parkinson's disease (PD) being at risk for aspiration. Methods: In this prospective, controlled, cross‐sectional study, we assessed if swallowing speed for water is a useful clinical test to predict aspiration proven by flexible endoscopic evaluation of swallowing (FEES). Due to this, we measured the swallowing speed for 90 mL water in 115 consecutive and unselected PD outpatients of all clinical stages and 32 healthy controls. Key Results: Average swallowing speed was lower in patients compared with controls (6.5 ± 3.9 mL/s vs 8.5 ± 3.2 mL/s; P < .01). The disease‐independent widely used threshold of <10 mL/s showed insufficient sensitivity of 88% and specificity of 19% with high false‐positive rates of 63% for patients and 69% for controls. Receiver operating characteristic (ROC) analysis was carried out to define a suitable cutoff value for detection of aspiration of water (area under the curve 0.72, P < .001) in PD patients. The optimized cutoff value was 5.5 mL/s with a sensitivity of 69% and a specificity of 64%. Conclusion and Inferences: Measuring swallowing speed is prone to methodological errors and not suitable as a screening instrument to predict aspiration in PD patients. [ABSTRACT FROM AUTHOR]