학술논문
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.
Document Type
Article
Author
Source
Subject
*CORNEAL transplantation
*NEOVASCULARIZATION
*VASCULAR endothelial growth factors
*CELLULAR immunity
*IMMUNOREGULATION
*CELL receptors
*CELLULAR signal transduction
*LYMPH nodes
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Language
ISSN
1078-8956
Abstract
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery. [ABSTRACT FROM AUTHOR]