학술논문
Clinical Significance of Tumor-Infiltrating T Cells and Programed Death Ligand-1 in Patients with Pancreatic Cancer.
Document Type
Journal Article
Author
Source
Subject
*ADENOCARCINOMA
*APOPTOSIS
*CANCER patients
*GENE expression
*LIGANDS (Biochemistry)
*PANCREATIC tumors
*T cells
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Language
ISSN
0735-7907
Abstract
The associations of the immunological status of the pancreatic ductal adenocarcinoma (PDA) microenvironment with prognosis were assessed. A high tumor-infiltrating lymphocyte (TIL) density was associated with a better prognosis. Importantly, even with a high density of TILs, the PDA cells with programed cell death-ligand 1 (PD-L1) expression showed a worse prognosis than the patients with negative PD-L1 expression. A significant association between a better prognosis and a tumor microenvironment with a high TIL density/negative PD-L1 expression was observed. Assessments of a combined immunological status in the tumor microenvironment may predict the prognosis of PDA patients following surgical resection. [ABSTRACT FROM AUTHOR]