학술논문
Rh(III)-catalyzed alkynylation: synthesis of functionalized quinolines from aminohydrazones.
Document Type
Article
Source
Subject
*QUINOLINE
*FUNCTIONAL groups
*BENZENE
*ALKYNES
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Language
ISSN
1359-7345
Abstract
Rhodium-catalyzed, chemo- and regioselective synthesis of functionalized quinolines using 2-aminohydrazones and terminal alkynes has been described. The reaction is oxidant/base-free and tolerates a wide variety of functional groups and has been successfully extended with 1,3 and 1,4-bis(phenylethynyl)benzenes to afford 1,3- and 1,4-bis(4-methylquinolin-2-yl)benzenes and 2-(3/4-ethynylphenyl)-4-methylquinolines. Furthermore, the control experiment supports the proposed reaction mechanism. [ABSTRACT FROM AUTHOR]