학술논문
Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon.
Document Type
Article
Author
Source
Subject
*DRUG therapy for malaria
*HEMOLYTIC anemia diagnosis
*ACUTE kidney failure
*CATASTROPHIC illness
*HEMOLYSIS & hemolysins
*HEMOLYTIC anemia
*HOSPITAL care
*PRIMAQUINE
*RISK assessment
*DISEASE prevalence
*THERAPEUTICS
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Language
ISSN
1058-4838
Abstract
Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax –infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100 000 primaquine users. [ABSTRACT FROM AUTHOR]