학술논문
The differential response to intermittent fasting diet versus low calorie diet with exercise based on -866 G/A UCP2 gene variation in adults with overweight/obesity.
Document Type
Article
Source
Subject
*LOW-calorie diet
*FASTING
*INTERMITTENT fasting
*WEIGHT loss
*EXERCISE
*NUTRITION counseling
*REDUCING exercises
*AEROBIC exercises
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Language
ISSN
1973-798X
Abstract
Background: The UCP2 gene variation has been associated with the increased risk for obesity and lower response to an energy-restricted diet. Objectives: This study aimed to compare the effect of intermittent fasting diet (IFD) and low-calorie diet with exercise (LCD-ex) based on UCP2 gene variations. Methods: Subjects were adult men and women (n = 125) with body mass index between 25–40 kg/m2. During IFD, subjects were abstained from eating and drinking for 13 hours. During LCD-ex, subjects received dietary counseling for low-calorie diet and group exercise program. Anthropometric changes were compared after 4 weeks. The -866 G/A (rs659366) UCP2 gene variation was analyzed and subjects were separated into 2 groups: GG and AA+GA. Results: In GG genotype, IFD was associated with a higher weight reduction compared to LCD-ex (–1.7±0.2 vs. –0.7±0.3 kg, p = 0.016). In AA+GA genotypes, there were no differences in weight loss between IFD and LCD-ex (–1.7±0.3 vs. –1.7±0.3 kg, p = 0.967). No differences in energy intake between genotypes (all p > 0.05). Conclusions: This study shows that GG genotype of -866 G/A UCP2 was associated with a better response towards IFD compared to LCD-ex. [ABSTRACT FROM AUTHOR]