학술논문
CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes.
Document Type
Journal Article
Author
Source
Subject
*BLOOD coagulation
*CELL culture
*CELL receptors
*COMPARATIVE studies
*EPITHELIAL cells
*HIV infections
*RESEARCH methodology
*MEDICAL cooperation
*MONOCYTES
*RESEARCH
*T cells
*THROMBOPLASTIN
*TUMOR necrosis factors
*EVALUATION research
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Language
ISSN
0022-1899
Abstract
Circulating CD8+ T cells and monocytes are activated during human immunodeficiency virus (HIV) infection and colocalize in the aortas of simian immunodeficiency virus-infected nonhuman primates. We hypothesized that CD8+ T cells could exert a proatherosclerotic effect via paracrine actions on monocytes. We found that T-cell receptor-stimulated CD8+ T cells induce monocytes to express tissue factor, a potent activator of coagulation. Tumor necrosis factor was both necessary and sufficient for this effect. [ABSTRACT FROM AUTHOR]