부산대학교 도서관

Background: People living with HIV (PLHIV) are at increased risk for developing cardiovascular disease (CVD). Cardiorespiratory fitness is the best indicator of CVD-related morbidity and mortality but is poorly understood in PLHIV. Physical activity improves cardiorespiratory fitness and reduces CVD, but physical activity is low in this population. Our objective was to describe physical activity and cardiorespiratory fitness by age and sex and to examine the association between physical activity and cardiorespiratory fitness in PLHIV. Methods: Seven-hundred and two PLHIV participated in a cross-sectional study and completed validated measures of self-reported physical activity (7-day physical activity recall & leisure time exercise questionnaire) and cardiorespiratory fitness (6-minute walk test [6MWT]). Clinical data were abstracted from participants' medical chart. Subjects were recruited from seven geographically diverse sites in the United States and Thailand. We analyzed physical activity and cardiorespiratory fitness with descriptive statistics and used multiple regression to examine the relationship between physical activity and cardiorespiratory fitness. Results: Participants engaged in 115 minutes of, mostly light (75%), physical activity in the past 7 days. Men reported twice the amount of total physical activity as women (155 vs 73 minutes, p =0.01). Participants' ability to achieve their age and sex- predicted 6MWT distances (meters) were similar between men (68%) and women (70%) (p >0.01). The ability to achieve predicted 6MWT distances increased with age for all participants (p <0.01). For women, vigorous physical activity was associated with a 6.6% increase in cardiorespiratory fitness (6MWT) and being temporarily unemployed was associated with a 18% decline in cardiorespiratory fitness, controlling for age, viral load, and season. Conclusions: PLHIV averaged 115 minutes of mostly light activity. Vigorous physical activity was associated with improved cardiorespiratory fitness in women, but not men. While all PLHIV would benefit from interventions to increase the amount and intensity of physical activity, our data suggest a need to develop sex-specific strategies to increase physical activity intensity. [ABSTRACT FROM AUTHOR]