학술논문
Hodgkin lymphoma of the elderly patients: a retrospective multicenter analysis from the Polish Lymphoma Research Group* .
Document Type
Article
Author
Wróbel, Tomasz; Rybka, Justyna; Dobrzyńska, Olga; Spychałowicz, Wojciech; Kalinka-Warzocha, Ewa; Kumiega, Beata; Drozd-Sokołowska, Joanna; Subocz, Edyta; Sałek, Agata; Machaczka, Maciej; Hołojda, Jadwiga; Pogrzeba, Joanna; Biecek, Przemysław; Szulgo, Anna; Sorbotten, Natalia; Chmielowska, Ewa; Giza, Agnieszka; Jurczak, Wojciech; Tyczyńska, Agata; Leśniewski-Kmak, Krzysztof
Source
Subject
*HODGKIN'S disease
*OLDER patients
*LYMPHOMAS
*
*
Language
ISSN
1042-8194
Abstract
We retrospectively analyzed long-term disease outcome of 350 elderly Hodgkin Lymphoma (eHL) patients treated with ABVD/ABVD-like regimen enrolled in the PLRG-R9 study between 2001 and 2013 in Poland. Complete remission was reported for 73% of early (ES) and 61% advanced stage (AS) patients. Nine (10%) ES and 56 (20%) AS patients have died. With the median follow-up of 36 (1-190) months, 3-year EFS and OS was 0.74 (95%CI: 0.63-0.85) and 0.90 (95%CI: 0.82-0.98) for ES; 0.51 (95%CI: 0.44-0.57), and 0.81 (95%CI: 0.75-0.86) for AS patients, respectively. For ES patients, Cox regression revealed ECOG <2 and age >70 as predictive for inferior OS and EFS. For AS patients, the most predictive for OS was the presence of cardiovascular disorders (CVD) (p = .00044), while for EFS four factors were significantly associated with a poor outcome: ECOG< 2, age >70 years, CVD and extranodal disease. In conclusion, CVD significantly impacts outcomes of ABVD-treated advanced eHL patients. [ABSTRACT FROM AUTHOR]