학술논문
Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study.
Document Type
Article
Author
Shalhoub, Sarah; Al-Hameed, Fahad; Mandourah, Yasser; Balkhy, Hanan H.; Al-Omari, Awad; Al Mekhlafi, Ghaleb. A.; Kharaba, Ayman; Alraddadi, Basem; Almotairi, Abdullah; Al Khatib, Kasim; Abdulmomen, Ahmed; Qushmaq, Ismael; Mady, Ahmed; Solaiman, Othman; Al-Aithan, Abdulsalam M.; Al-Raddadi, Rajaa; Ragab, Ahmed; Al Harthy, Abdulrahman; Al Qasim, Eman; Jose, Jesna
Source
Subject
*MIDDLE East respiratory syndrome
*MEDICAL care
*CATASTROPHIC illness
*KIDNEYS
*HOSPITAL admission & discharge
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Language
ISSN
1932-6203
Abstract
Background: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) leads to healthcare-associated transmission to patients and healthcare workers with potentially fatal outcomes. Aim: We aimed to describe the clinical course and functional outcomes of critically ill healthcare workers (HCWs) with MERS. Methods: Data on HCWs was extracted from a multi-center retrospective cohort study on 330 critically ill patients with MERS admitted between (9/2012–9/2015). Baseline demographics, interventions and outcomes were recorded and compared between survivors and non-survivors. Survivors were approached with questionnaires to elucidate their functional outcomes using Karnofsky Performance Status Scale. Findings: Thirty-Two HCWs met the inclusion criteria. Comorbidities were recorded in 34% (11/32) HCW. Death resulted in 8/32 (25%) HCWs including all 5 HCWs with chronic renal impairment at baseline. Non-surviving HCW had lower PaO2/FiO2 ratios 63.5 (57, 116.2) vs 148 (84, 194.3), p = 0.043, and received more ECMO therapy compared to survivors, 9/32 (28%) vs 4/24 (16.7%) respectively (p = 0.02).Thirteen of the surviving (13/24) HCWs responded to the questionnaire. Two HCWs confirmed functional limitations. Median number of days from hospital discharge until the questionnaires were filled was 580 (95% CI 568, 723.5) days. Conclusion: Approximately 10% of critically ill patients with MERS were HCWs. Hospital mortality rate was substantial (25%). Patients with chronic renal impairment represented a particularly high-risk group that should receive extra caution during suspected or confirmed MERS cases clinical care assignment and during outbreaks. Long-term repercussions of critical illness due to MERS on HCWs in particular, and patients in general, remain unknown and should be investigated in larger studies. [ABSTRACT FROM AUTHOR]