학술논문
Association between Common Toll-Like Receptor 4 Mutations and Severe Respiratory Syncytial Virus Disease.
Document Type
Article
Author
Source
Subject
*RESPIRATORY syncytial virus
*INFANT diseases
*GENETICS of virus diseases
*NATURAL immunity
*GENETIC mutation
*GENETIC polymorphisms
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Language
ISSN
0022-1899
Abstract
The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy infants is extremely variable. Thus, it is likely that factors such as genetic heterogeneity contribute to disease severity. Toll-like receptor 4 (TLR4) and CD14 are part of a receptor complex involved in the innate immune response to RSV. Each of the TLR4 mutations, either alone or in cosegregation, were associated with severe RSV bronchiolitis: the Asp299Gly and Thr399Ile mutations were significantly overrepresented in group I, compared with groups II and III. No association between the CD14/ 159 polymorphism and RSV bronchiolitis was found. These findings suggest that TLR4 mutations, but not the CD14/ 159 polymorphism, are associated with an increased risk of severe RSV bronchiolitis in previously healthy infants. [ABSTRACT FROM AUTHOR]