학술논문
Linking PRMT5 to breast cancer stem cells: New therapeutic opportunities?
Document Type
Article
Author
Source
Subject
*METHYLTRANSFERASES
*CANCER invasiveness
*BREAST cancer
*CANCER stem cells
*EPIGENETICS
*DISEASE relapse
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Language
ISSN
2372-3556
Abstract
The arginine methyltransferase PRMT5 has been increasingly associated with cancer development. Here we describe our recent findings that PRMT5 is a critical regulator of breast cancer stem cell survival via the epigenetic regulation of FOXP1. Consequently, PRMT5 inhibitors could potentially eradicate cancer stem cells thereby preventing tumour relapse. [ABSTRACT FROM AUTHOR]