부산대학교 도서관

Borderline ovarian tumors (BOT) are a heterogeneous group of epithelial tumors of the ovaries with both malignant and non-malignant aspects. They are characterized by cellular proliferation and nuclear atypia, but they usually do not show infiltrative growth pattern. BOT comprise about 15% of all epithelial ovarian malignancies. Patients with BOT are, in general, 10 years younger than women with epithelial ovarian cancer. Approximately one-third of all BOT are diagnosed in patients with child-bearing potential. Balancing radicality between oncologic safety and fertility-sparing treatment is a challenging task. We evaluated the clinical parameters of BOT patients treated between 1.01.2014 and 31.12.2017 in the 1st Department of General and Oncologic Surgery, “Prof. Dr. Al. Trestioreanu” Institute of Oncology, Bucharest. The median age of the 37 patients was 48.2 years old, 14 patients were under 40 years old (37.8%), and fertility-preserving surgery was carried-out in 57.1% of the cases (8 patients). As they affect more frequently younger patients, the clinical management of BOT is complicated by aspects regarding the preservation of fertility. Despite a more favourable overall survival, young BOT patients with fertility-preserving surgery are at higher risk for disease recurrence. A better characterization of high-risk subtypes is crucial to better understand long-term risk of BOT and to avoid recurrences in those patients undertreated by the current management strategies. Fertility-sparing approach can be justified for younger patients after a thorough consultation. [ABSTRACT FROM AUTHOR]