학술논문
Highly selective nicotinohydrazide based ‘turn-on’ chemosensor for the detection of bioactive zinc(II): Its biocompitability and bioimaging application in cancer cells.
Document Type
Article
Author
Source
Subject
*SCHIFF bases
*ADVANCED glycation end-products
*CANCER cells
*CHROMOGENIC compounds
*CHELATION therapy
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Language
ISSN
0925-4005
Abstract
A novel optically active (E)-N’-(5-allyl-2-hydroxy-3-methoxybenzylidene) nicotinohydrazide (receptor 3) was synthesized by simple Schiff base condensation of 5-allyl-2-hydroxy-3-methoxybenzaldehyde with nicotinohydrazide. The ability of receptor 3 was investigated for the selective sensing of cations by chromogenic and fluorogenic technique. Receptor 3 showed highly selective response for Zn 2+ ions in the binary mixture of acetonitrile/water (50:50, v/v) and possessed no interference from any of the potentially competing cations. Upon additions of Zn 2+ , the fluorescence intensity of the receptor 3 showed significant enhancement at 517 nm due to the chelation-enhanced fluorescence (CHEF) effect. The receptor 3 showed a good linearity for Zn 2+ ion with the detection limit down to 4.35 nM. With negligible toxicity towards live cells, the receptor 3 could be successfully employed to monitor the Zn 2+ ions in live A549 cells. [ABSTRACT FROM AUTHOR]