학술논문
Preparation of ibuprofen/hydroxypropyl-γ-cyclodextrin inclusion complexes using supercritical CO2-assisted spray drying.
Document Type
Article
Author
Source
Subject
*IBUPROFEN
*INCLUSION compounds
*CYCLODEXTRINS
*SUPERCRITICAL fluids
*ANTIOXIDANTS
*SPRAY drying
*SUPERCRITICAL carbon dioxide
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Language
ISSN
0896-8446
Abstract
Herein we report the formation of dry powder complexes of ibuprofen (IBU) and hydroxypropyl-γ-cyclodextrin (HP-γ-CyD) by supercritical CO 2 -assisted spray-drying (SASD). SASD of HP-γ-CyD alone, IBU/HP-γ-CyD, as well as the physical mixture were prepared and characterized using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), ultra-violet spectroscopy (UV), 13 C cross-polarization magic angle spinning nuclear magnetic resonance ( 13 C CP/MAS NMR), differential scanning calorimetry (DSC) and morphological studies. Results indicate the successful formation of amorphous inclusion complexes. SASD is a clean technology, suitable for processing thermolabile APIs, thus an interesting alternative to conventional spray drying and other methods of CyD solid complex formation. [ABSTRACT FROM AUTHOR]