학술논문
Donor lymphocyte infusions for refractory pure red cell aplasia relapsing after both autologous and nonmyeloablative allogeneic peripheral stem cell transplantation.
Document Type
Article
Author
Source
Subject
*PURE red cell aplasia
*IMMUNOSUPPRESSIVE agents
*HEMATOPOIETIC stem cell transplantation
*FLUDARABINE
*GRAFT versus host reaction
*AUTOIMMUNE diseases
*THERAPEUTICS
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Language
ISSN
0268-3369
Abstract
Summary:Pure red cell aplasia (PRCA) is characterized by a selective marrow aplasia of the erythroid compartment. Immunosuppressive therapy achieves good results in about 25% of cases, but relapses are frequent. Autologous or allogeneic haematopoietic stem cell transplantation (HSCT) may be valuable in selected patients. Here, we report details of a 29-year-old woman treated successfully by donor lymphocyte infusions (DLIs) following allogeneic HSCT for acquired refractory relapsed PRCA. The nonmyeloablative conditioning regimen consisted of cyclophosphamide 60?mg/kg/day for 2 days and fludarabine 30?mg/m2 daily for 4 days. Haematopoiesis was still completely ‘recipient’ 1 month after allo-HSCT, but progressed to full donor engraftment after three doses of ‘escalating’ DLI. The possible role of a graft-versus-autoimmunity effect induced by allogeneic HSCT followed by DLI infusions in the treatment of the disease is discussed.Bone Marrow Transplantation (2004) 33, 769-771. doi:10.1038/sj.bmt.1704419 Published online 2 February 2004 [ABSTRACT FROM AUTHOR]