부산대학교 도서관

Introduction: Overweight has become a common health problem all over the world. Adolescent age is a critical period in determining the adulthood obesity and its adverse health consequences. Adiponectin, an adipocytokine which has a close association with metabolic profiles of obesity-related diseases particularly lipid variables. Therefore this study was carried out to investigate those associations in Malaysian adolescent population. Objective: This study aimed to find the correlation of adiponectin with lipid profile in overweight group and normal weight group. Methods: This study was carried out on 58 overweight adolescents and 60 normal weight adolescents attended National Training Service Programme who fulfilled the inclusion and exclusion criteria. Serum adiponectin, fasting serum insulin, fasting serum lipid profile and fasting plasma glucose were analyzed. Insulin resistance was obtained by HOMA-IR formula. Results: The mean adiponectin concentration was significantly lower in overweight subjects compared to normal weight subjects (P = 0.005). The mean plasma glucose concentration was higher in normal weight group than overweight group (P = 0.04). The mean total cholesterol and mean HDL cholesterol concentrations were lower in overweight subjects compared to normal weight subjects (P = 0.008, P < 0.001). There was a significant correlation noted between adiponectin and HDL-cholesterol in overweight group (P = 0.004). There were no significant correlations between adiponectin and other lipid variables as well as other metabolic profiles measured. Conclusion: Our study supports that serum adiponectin has a role in the treatment obesity and its related complications. This is evidenced by the lower level of this hormone in overweight subjects and the significant positive correlation between adiponectin and HDL-cholesterol in overweight subjects.