학술논문
Prediction of the antibacterial activity of garlic extract on E. coli, S. aureus and B. subtilis by determining the diameter of the inhibition zones using artificial neural networks.
Document Type
Article
Source
Subject
*THERAPEUTIC use of garlic
*ANTIBACTERIAL agents
*ARTIFICIAL neural networks
*MACHINE learning
*SENSITIVITY analysis
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Language
ISSN
0023-6438
Abstract
The aim of this study was to devise a model that predicts the inhibition zone diameter using artificial neural networks. The concentration, temperature and the exposure time of our extract were taken as input variables. The neural architecture model 3-13-3 and a learning algorithm Quasi-Newton (BFGS) revealed a positive correlation between the experimental results and those artificially predicted, which were measured according to a mean squared error (RMSE) and an R 2 coefficient of E. coli (RMSE = 1.28; R 2 = 0,96), S. aureus (RMSE = 1.46; R 2 = 0,97) and B. subtilis (RMSE = 1.88; R 2 = 0,96) respectively. Based on these results, an external and an internal model validation were attained. A neuronal mathematical equation was created to predict the inhibition diameters for experimental data not included in the basic learning. Consequently, a good correlation was observed between the values predicted by the equation and those obtained experimentally, as demonstrated by the R 2 and RMSE values. The results regarding the sensitivity analysis showed that the concentration was the most determinant parameter compared to Temperature and Time variables. Ultimately, the model developed in this study will be used reliably to predict the variation of garlic extract's inhibition diameter. [ABSTRACT FROM AUTHOR]