학술논문
Propeptide big-endothelin, N-terminal-pro brain natriuretic peptide and mortality. The Ludwigshafen risk and cardiovascular health (LURIC) study.
Document Type
Article
Author
Source
Subject
*ENDOTHELINS
*NATRIURETIC peptides
*CARDIOVASCULAR diseases
*CAUSES of death
*CORONARY angiography
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Language
ISSN
1354-750X
Abstract
Context:The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF). Objectives:We have examined the incremental value of Big-ET-1 in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP). Methods:Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years). Results:Big-ET-1 is an independent predictor of total, CV mortality and death due to CHF. Discussion:The conjunct use of Big-ET-1 and NT-proBNP improves the risk stratification of patients with intermediate to high risk of CV death and CHF. Conclusions:Big-ET-1improves risk stratification in patients referred for coronary angiography. [ABSTRACT FROM PUBLISHER]