학술논문
Design, synthesis and antibacterial evaluation of 2-alkyl- and 2-aryl-3-(phenylamino)quinazolin-4(3H)-one derivatives.
Document Type
Article
Source
Subject
*QUINAZOLINE
*CHEMICAL synthesis
*ANTI-infective agents
*CONDENSATION
*ANHYDRIDES
*PHENYLHYDRAZINE
*
*
*
*
*
Language
ISSN
0793-0283
Abstract
2-Alkyl and 2-aryl-3-(phenylamino)quinazolin-4(3H)-ones 4a-h were synthesized in a one-pot three-component condensation of an isatoic anhydride 1a-h, ethyl or methyl ortho ester and phenylhydrazine in the presence of KAl(SO4)2 · 12H2O (alum) as a nontoxic, reusable, inexpensive and easily available catalyst. The synthesis was conducted under microwave irradiation or classical heating. Products 4a and 4b show good antimicrobial activities. [ABSTRACT FROM AUTHOR]