부산대학교 도서관

Background Pain and inflammation are associated with the pathophysiology of various clinical conditions. Most analgesic and anti-inflammatory drugs available in the market present a wide range of problems. The current study was aimed at investigating the analgesic and anti-inflammatory activity of 80% methanol extract of J. abyssinicum root. Methods The analgesic activity was determined using tail-flick test and acetic acid induced writhing, whereas anti-inflammatory activity was determined by carrageenan induced paw edema and formalin induced pedal edema, carried out in vivo. The test group received three different doses of the extract (50 mg/kg, 100 mg/kg and 200 mg/kg) orally. The positive control group received diclofenac (10 mg/kg), aspirin (100 mg/kg or 150 mg/kg) or morphine (20 mg/kg) orally. The negative control group received vehicle (2% Tween 80, 10 ml/kg) orally. Furthermore, preliminary phytochemical screening was carried out. Results Oral administration of J. abbysinicum 80% methanol extract (at all doses) significantly (p<0.001) inhibit pain sensation in the pain models. Similarly, the extract demonstrated anti-inflammatory effect in the inflammation models in mice. Preliminary phytochemical screening showed the presence of saponins, flavonoids, terpenoids, triterpenens and glycosides. Conclusion The data obtained from the present study indicates that the extract possessed a significant analgesic and anti-inflammatory activity, upholding the folkloric use of the plant. [ABSTRACT FROM AUTHOR]