학술논문
Spread and Evolution of Respiratory Syncytial Virus A Genotype ON1, Coastal Kenya, 2010-2015.
Document Type
Journal Article
Author
Source
Subject
*RESPIRATORY syncytial virus
*GENOTYPES
*PNEUMONIA in children
*MICROBIAL virulence
*AMINO acids
*COMPARATIVE studies
*BIOLOGICAL evolution
*GENETICS
*HISTORY
*RESEARCH methodology
*MEDICAL cooperation
*PROTEINS
*PUBLIC health surveillance
*RESEARCH
*RESEARCH funding
*EVALUATION research
*RESPIRATORY syncytial virus infections
*SEQUENCE analysis
*ODDS ratio
*DIAGNOSIS
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Language
ISSN
1080-6040
Abstract
In February 2012, the novel respiratory syncytial virus (RSV) group A, genotype ON1, was detected in Kilifi County, coastal Kenya. ON1 is characterized by a 72-nt duplication within the highly variable G gene (encoding the immunogenic attachment surface protein). Cases were diagnosed through surveillance of pneumonia in children at the county hospital. Analysis of epidemiologic, clinical, and sequence data of RSV-A viruses detected over 5 RSV seasons (2010/2011 to 2014/2015) indicated the following: 1) replacement of previously circulating genotype GA2 ON1, 2) an abrupt expansion in the number of ON1 variants detected in the 2014/2015 epidemic, 3) recently accumulation of amino acid substitutions within the ON1 duplicated sequence, and 4) no clear evidence of altered pathogenicity relative to GA2. The study demonstrates the public health importance of molecular surveillance in defining the spread, clinical effects, and evolution of novel respiratory virus variants. [ABSTRACT FROM AUTHOR]