부산대학교 도서관

Key Content: Cytomegalovirus (CMV) is the most common cause of congenital viral infections; 75–90% of infections are asymptomatic at birth but 10–25% of infants will develop neurological sequelae.Diagnosis of primary maternal CMV in pregnancy should be based on seroconversion in pregnancy (de novo appearance of virus‐specific immunoglobulin G [IgG] in the serum of pregnant women who were previously seronegative) or on detection of specific immunoglobulin M (IgM) and IgG antibodies in association with low IgG avidity.Primary maternal infection is associated with a 30–40% risk of intrauterine transmission and fetal infection, with 20–25% of those infected developing sequelae postnatally.Prenatal diagnosis of fetal CMV is imperfect and based on amniocentesis performed at least 7 weeks after presumed maternal infection and after 21 weeks of gestation.The presence of radiologic findings by ultrasound in combination with CMV DNA viral load in amniotic fluid may have prognostic significance for risk of neurologic sequelae. Learning objectives: To understand the prevalence, diagnosis and implications of CMV infection in pregnancy.To explore the management options in a pregnancy affected by congenital CMV. Ethical issues: Should routine screening for CMV be recommended in pregnancy?How should termination counselling be conducted following prenatal confirmation of fetal infection with amniocentesis? [ABSTRACT FROM AUTHOR]