학술논문
Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease.
Document Type
Journal Article
Author
Farage Frade, Amanda; Laugier, Laurie; Rodrigues Pinto Ferreira, Ludmila; Andrade Baron, Monique; Benvenuti, Luiz Alberto; Camillo Teixeira, Priscila; Cunha Navarro, Isabela; Cabantous, Sandrine; Moraes Ferreira, Frederico; da Silva Cândido, Darlan; Gaiotto, Fabio Antônio; Bacal, Fernando; Pomerantzeff, Pablo; Barros Santos, Ronaldo Honorato; Kalil, Jorge; Cunha-Neto, Edecio; Chevillard, Christophe; Frade, Amanda Farage; Ferreira, Ludmila Rodrigues Pinto; Baron, Monique Andrade
Source
Subject
*CLOSTRIDIOIDES difficile
*IMMUNOGLOBULINS
*ANTIBODY formation
*IMMUNE system
*IMMUNOGLOBULIN class switching
*ANIMAL experimentation
*MICE
*MYOCARDIAL infarction
*RNA
*TRANSCRIPTION factors
*TRYPANOSOMIASIS
*GENE expression profiling
*DISEASE complications
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Language
ISSN
0022-1899
Abstract
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC. [ABSTRACT FROM AUTHOR]