부산대학교 도서관

Objective: Human leukocyte antigens (HLA) have been associated with periodontitis. Previous studies revealed HLA-A9 and HLA-B15 as potential susceptibility factors, while HLA-A2 and HLA-B5 might have protective effects. The aim of the study was to verify these associations in a group of HLA-typed blood donors with previously unknown periodontal status. Materials and methods: In four German centers, 140 blood donors with known HLA class I status were enrolled and allocated to the following five groups: HLA-A9 ( N = 24), HLA-B15 ( N = 20), HLA-A2 ( N = 30), HLA-B5 ( N = 26), and controls ( N = 40). Periodontal examination included the measurement of probing depths (PDs), clinical attachment level (CAL), bleeding on probing (BOP), and community periodontal index of treatment needs (CPITN). Results: Carriers with HLA-A9 and HLA-B15 had higher values of mean PD ( P < 0.0001), CAL ( P < 0.0001), and BOP ( P < 0.002) as well as sites with PD and CAL with ≥4 and ≥6 mm ( P < 0.0003), respectively, than controls. Multiple regression analyses revealed HLA-A9, HLA-B15, and smoking as risk indicators for moderate to severe (CPITN 3-4; odds ratio (OR): 66.7, 15.3, and 5.1) and severe (CPITN 4; OR: 6.6, 7.4, and 3.8) periodontitis. HLA-A2 and HLA-B5 did not show any relevant associations. Conclusion: The present data support a role of HLA-A9 and HLA-B15 as susceptibility factors for periodontitis, whereas HLA-A2 and HLA-B5 could not be confirmed as resistance factors. Clinical relevance: Both HLA antigens A9 and B15 are potential candidates for periodontal risk assessment. [ABSTRACT FROM AUTHOR]