학술논문
Nucleolar DNA: the host and the guests.
Document Type
Article
Author
Source
Subject
*GENETIC code
*GENE silencing
*TRANSCRIPTION factors
*NUCLEAR DNA
*NUCLEOLUS
*RIBOSOMAL RNA
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*
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Language
ISSN
0948-6143
Abstract
Nucleoli are formed on the basis of ribosomal genes coding for RNAs of ribosomal particles, but also include a great variety of other DNA regions. In this article, we discuss the characteristics of ribosomal DNA: the structure of the rDNA locus, complex organization and functions of the intergenic spacer, multiplicity of gene copies in one cell, selective silencing of genes and whole gene clusters, relation to components of nucleolar ultrastructure, specific problems associated with replication. We also review current data on the role of non-ribosomal DNA in the organization and function of nucleoli. Finally, we discuss probable causes preventing efficient visualization of DNA in nucleoli. [ABSTRACT FROM AUTHOR]