학술논문
Maturation and Aging-Related Differences in Responsiveness of Rat Aorta and Carotid Arteries to α[sub 1] -Adrenoceptor Stimulation.
Document Type
Article
Source
Subject
*MATURATION (Psychology)
*AGING
*RATS
*CAROTID artery
*AORTA
*ALPHA adrenoceptors
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Language
ISSN
0031-7012
Abstract
Functional correlates of α[sub 1] -adrenoceptors were studied in thoracic aorta and carotid arteries from Wistar rats, at maturation (3- and 8-week-old) and aging (17- and 29-week-old) phases, using phenylephrine (PHE) and KCl. PHE and KCl effects on rat aorta did not differ with age. A reduction in maximal contractions to PHE or KCl occurred in carotid arteries during maturation. Concentration-inhibition curves to the alkylating agent chloroethylclonidine or WB4101 suggested at all ages studied a predominance of α[sub 1B] -adrenoceptors in aorta. However, α[sub 1A] -adrenoceptors may account for some activity in aortas of 29-week-old rats. In carotid arteries α[sub 1D] -adrenoceptors account for functional correlates at all ages studied. The results indicate that maturation or aging affects vascular responsiveness or predominant receptor subtype differently in aorta and carotid arteries with intact endothelium. [ABSTRACT FROM AUTHOR]